Undenatured collagen is collagen that has been processed to preserve its natural molecular structure. Unlike hydrolysed collagen, which is broken down into smaller peptides, undenatured collagen retains important structural features of the original collagen molecule.
This distinction is particularly important for Type II collagen. Its preserved structure allows it to interact with the immune system in a different way from collagen peptides.
Research has investigated undenatured Type II collagen for joint health, including its potential to support joint comfort, mobility and healthy immune responses through a mechanism known as oral tolerance.