Clinical research on undenatured Type II collagen has produced promising results for joint health.
Randomised controlled studies have investigated doses of 40 mg daily and reported improvements in measures including knee flexibility, joint function and exercise-related discomfort.
A 2025 systematic review identified 12 studies investigating undenatured Type II collagen for knee osteoarthritis and concluded that the evidence supports potential benefits for pain, function and range of motion, while also highlighting the need for larger, longer-term trials.
The evidence continues to develop.